Oxidative Stress and Cardiovascular Injury

Oxidative Stress and Cardiovascular Diseases

Reactive oxygen species (ROS) are reactive oxygen metabolites resulting from one-electron reduction of oxygen under the influence of a variety of enzymes. In aerobic organisms, they are produced as a byproduct of many cellular metabolic pathways and participate in some processes necessary for the normal life and functioning of the cells, but also in a large number of pathological processes. Oxi...

Cardiovascular Genomics and Oxidative Stress

The majority of modifiable cardiovascular risk factors are complex, polygenic, or at least oligogenic traits, with genetic and environmental determinants playing important roles in disease risk and its phenotypic expression. The Human Genome Project and subsequent mouse and rat genome data have provided powerful tools to commence the dissection of genetic determinants of hypertension and other ...

Oxidative stress in cardiovascular disease.

Over the last two decades, it has become increasingly clear that reactive oxygen species (ROS), including free radicals are involved in cardiovascular disease. In recent years, there has been a growing interest in the clinical implications of these oxidants. The ROS are common by-products of many oxidative biochemical and physiological processes. They can be released by xanthine oxidase, NAD(P)...

Oxidative Stress in Cardiovascular Disease

In the special issue "Oxidative Stress in Cardiovascular Disease" authors were invited to submit papers that investigate key questions in the field of cardiovascular free radical biology. The original research articles included in this issue provide important information regarding novel aspects of reactive oxygen species (ROS)-mediated signaling, which have important implications in physiologic...

Oxidative Stress and Inflammation in Cardiovascular Disease